Description

Chlorpheniramine n-Oxide is a key pharmaceutical intermediate and metabolite of the widely used antihistamine, chlorpheniramine. This compound is of significant importance for research and development in pharmacology and analytical chemistry, particularly in metabolic pathway studies and impurity profiling. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug development, quality control, and regulatory compliance work.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and research of antihistamine drugs and their related analogs.
• Metabolite Reference Standard: Used as a certified reference material (CRM) for pharmacokinetic and drug metabolism studies in preclinical and clinical research.
• Analytical Standard: Essential for developing and validating analytical methods (e.g., HPLC, LC-MS) for impurity identification and assay of chlorpheniramine-based pharmaceuticals.
• Quality Control & Assurance: Serves as a system suitability standard and an impurity marker in the quality control laboratories of API and finished dosage form manufacturers.
• Regulatory Compliance: Supports regulatory filings (e.g., with FDA, EMA) by providing characterized material for stability studies and impurity qualification.
• Academic & Biomedical Research: Employed in university and institutional research to study histamine receptor interactions and metabolic biotransformations.

Basic Information

Product Name	Chlorpheniramine n-Oxide
CAS No.	142494-45-9
Molecular Formula	C16H19ClN2O
Molecular Weight	290.79 g/mol
Synonyms	Chlorpheniramine N-Oxide; Chlorphenamine N-Oxide; 2-[p-Chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine N-Oxide; 1-(4-Chlorophenyl)-1-(2-pyridyl)-3-(dimethylamino)propan-1-ol N-Oxide; Chlorpheniramine Oxide; Chlorphenamine Oxide; Histafen N-Oxide; Piriton N-Oxide
EINECS	Contact for details

Quality Control

Our Chlorpheniramine n-Oxide is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via advanced techniques like HPLC and LC-MS, to ensure it meets high-purity standards suitable for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.