Description

Methyl n-Butylsulfonyl-L-p-Hydroxyphenylalanine CAS NO 142374-01-4 is a specialized, high-purity chiral amino acid derivative designed for advanced pharmaceutical and biochemical research. This compound serves as a critical synthetic intermediate or building block for the development of novel therapeutic agents, particularly in the fields of protease inhibitors and peptide-based drugs. It is essential for research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), especially for protease inhibitors and other peptide-mimetic drugs.
• Peptide Chemistry Research: Used in the design and solid-phase synthesis of novel peptides for drug discovery and biochemical studies.
• Protease Inhibitor Development: Serves as a core structural component in the research and development of specific enzyme inhibitors.
• Bioconjugation & Labeling: The reactive sulfonyl and hydroxyl groups make it suitable for creating labeled probes or conjugates for diagnostic applications.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective organic synthesis to introduce specific stereocenters.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Methyl n-Butylsulfonyl-L-p-Hydroxyphenylalanine
CAS No.	142374-01-4
Molecular Formula	C15H23NO6S
Molecular Weight	345.41 g/mol
Synonyms	L-p-Hydroxyphenylalanine, N-(n-Butylsulfonyl)-, methyl ester; Methyl N-(n-butylsulfonyl)-L-tyrosinate; (2S)-2-[(Butylsulfonyl)amino]-3-(4-hydroxyphenyl)propanoic acid methyl ester; Methyl (2S)-2-(butylsulfonylamino)-3-(4-hydroxyphenyl)propanoate; N-Butylsulfonyl-L-tyrosine methyl ester; BOC Sciences Brand Name: BBL-S-7592; L-Tyrosine, N-(butylsulfonyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl n-Butylsulfonyl-L-p-Hydroxyphenylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, identity confirmation by IR and NMR, and stringent control of related substances. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.