Description

1-Boc-3-(Cyanomethyl)Azetidine is a high-purity, protected heterocyclic building block of significant value in modern synthetic chemistry. Its core value lies in its bifunctional structure, featuring a Boc-protected secondary amine and a reactive cyanomethyl group, enabling its use as a versatile intermediate for constructing complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the azetidine ring system, which is a valuable bioisostere in medicinal chemistry.
• Peptidomimetic Synthesis: Used to create constrained peptide analogs and peptidomimetics by incorporating the rigid azetidine scaffold, potentially improving metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and insecticides that utilize heterocyclic cores for enhanced activity.
• Chemical Biology Probes: Useful for creating tool compounds and molecular probes to study biological pathways and enzyme functions.
• Polymer Modification: Can be used to introduce functional groups into polymer backbones for specialty materials with tailored properties.

Basic Information

Product Name	1-Boc-3-(Cyanomethyl)Azetidine
CAS No.	142253-58-5
Molecular Formula	C10H16N2O2
Molecular Weight	196.25 g/mol
Synonyms	tert-Butyl 3-(cyanomethyl)azetidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-(cyanomethyl)azetidine; 3-(Cyanomethyl)azetidine-1-carboxylic acid tert-butyl ester; 1-Boc-3-cyanomethylazetidine; Azetidine-1-carboxylic acid, 3-(cyanomethyl)-, 1,1-dimethylethyl ester; Boc-3-cyanomethyl-azetidine; 1-N-Boc-3-(cyanomethyl)azetidine
EINECS	Contact for details

Quality Control

Our 1-Boc-3-(Cyanomethyl)Azetidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.