Description

1-n-Boc-3-Azetidinecarboxylic Acid is a versatile and high-purity Boc-protected azetidine derivative, essential for advanced organic synthesis. This compound serves as a critical building block for introducing the constrained, three-membered azetidine ring system into target molecules, a feature highly valued in modern medicinal chemistry for modulating physicochemical and pharmacokinetic properties. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates containing the azetidine moiety, which is increasingly explored in areas like kinase inhibitors, protease inhibitors, and GPCR modulators.
• Peptidomimetics & Constrained Analogues: Used to create conformationally restricted peptide analogues to enhance metabolic stability, bioavailability, and receptor selectivity.
• Agrochemical Research: Employed in the discovery and development of new herbicides, fungicides, and insecticides that benefit from the unique spatial geometry of the azetidine ring.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Potential monomer or cross-linking agent for creating polymers with specific thermal or mechanical properties.
• Chemical Biology Probes: Useful for labeling studies or as a component in activity-based probes to study enzyme function.

Basic Information

Product Name	1-n-Boc-3-Azetidinecarboxylic Acid
CAS No.	142253-55-2
Molecular Formula	C9H15NO4
Molecular Weight	201.22 g/mol
Synonyms	3-((tert-Butoxycarbonyl)amino)azetidine-3-carboxylic Acid; 1-Boc-3-carboxyazetidine; 3-Azetidinecarboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-; tert-Butyl 3-carboxyazetidine-1-carboxylate; 1-(tert-Butoxycarbonyl)azetidine-3-carboxylic Acid; Boc-Azetidine-3-carboxylic Acid; Boc-Aze(3)-OH; (1-Boc-3-azetidinyl)carboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-n-Boc-3-Azetidinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.