Description

4'-Hydroxyphenyl Carvedilol Sulfate Ammonium Salt is a key pharmaceutical intermediate and reference standard of significant importance in modern drug development and quality control. This compound is critical for ensuring the purity, potency, and safety of related active pharmaceutical ingredients (APIs) and finished drug products. It is primarily needed by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in cardiovascular drug development, process optimization, and regulatory compliance testing.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced carvedilol derivatives and related cardiovascular APIs.
• Analytical Reference Standard: Used for method development, validation, and routine quality control (QC) testing in HPLC, LC-MS, and other chromatographic systems.
• Impurity Profiling: Serves as a certified reference material for identifying and quantifying related substances and degradation products in carvedilol drug substances and products.
• Metabolite Studies: Employed in pharmacokinetic and pharmacodynamic research to study the metabolism and biological activity of carvedilol.
• Process Development: Utilized in scaling up and optimizing synthetic routes within pharmaceutical R&D and manufacturing.
• Regulatory Compliance: Essential for generating data to meet stringent regulatory requirements from agencies like the FDA, EMA, and PMDA.

Basic Information

Product Name	4'-Hydroxyphenyl Carvedilol Sulfate Ammonium Salt
CAS No.	142227-52-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Carvedilol Impurity; Carvedilol Related Compound; 4'-Hydroxy Carvedilol Sulfate Ammonium Salt; 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-hydroxyphenoxy)ethyl]amino]-2-propanol Sulfate Ammonium Salt; Ammonium 4'-Hydroxyphenyl Carvedilol Sulfate; Carvedilol Sulfate Salt; Carvedilol Metabolite Reference Standard
EINECS	Contact for details

Quality Control

Our 4'-Hydroxyphenyl Carvedilol Sulfate Ammonium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical analysis and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by validated methods (e.g., HPLC, NMR) is provided with every shipment to support your quality and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.