Description

Amyloid β-Protein (1-12) CAS NO 142047-91-4 is a synthetic peptide fragment corresponding to the first twelve amino acids of the human amyloid beta (Aβ) protein. This specific sequence is of critical importance for fundamental research into the molecular mechanisms of Alzheimer's disease and other amyloid-related disorders. It serves as an essential biochemical tool for scientists and researchers in the fields of neuroscience, biochemistry, and pharmaceutical development, enabling studies on protein aggregation, antibody binding, and diagnostic assay development.

Application

• Neuroscience Research: Used as a key reagent in studies investigating the aggregation kinetics, toxicity, and structural properties of amyloid beta peptides, which are central to Alzheimer's disease pathology.
• Antibody Development & Validation: Serves as a critical antigen for the production, screening, and characterization of monoclonal and polyclonal antibodies targeting the N-terminal region of Aβ.
• Diagnostic Assay Development: Employed in the development and calibration of immunoassays (ELISA, Western Blot) for the detection and quantification of Aβ peptides in biological samples.
• Biophysical Studies: Utilized in spectroscopic analysis (e.g., NMR, CD spectroscopy) and computational modeling to understand the early conformational changes and interactions of Aβ peptides.
• Drug Discovery Screening: Acts as a target compound in high-throughput screening platforms to identify potential therapeutic molecules that inhibit Aβ aggregation or promote its clearance.
• Academic & Pharmaceutical R&D: Provides a defined, high-purity standard for basic research and pre-clinical development within university laboratories and biopharmaceutical companies.

Basic Information

Product Name	Amyloid β-Protein (1-12)
CAS No.	142047-91-4
Molecular Formula	C60H89N17O19
Molecular Weight	1320.5 g/mol
Synonyms	Aβ(1-12); Amyloid Beta Protein Fragment 1-12; Amyloid β-Peptide (1-12); DAEFRHDSGYEV; Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val; β-Amyloid (1-12); Aβ1-12; Alzheimer's Disease Amyloid Peptide (1-12)
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (1-12) is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including reverse-phase HPLC for purity assessment and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use vials to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Solubility	Soluble in water or dilute aqueous acetic acid
Single Peak by HPLC	Pass

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.