Description

4-(Trifluoromethyl)-Dl-Phenylglycine is a non-natural amino acid derivative characterized by the presence of a trifluoromethyl group on the phenyl ring. This compound matters as a versatile chiral building block and intermediate, where the fluorine atoms impart unique electronic and steric properties critical for modulating the biological activity and metabolic stability of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, process development, and the synthesis of novel active ingredients.

Application

• Pharmaceutical intermediate for the synthesis of active pharmaceutical ingredients (APIs).
• Chiral building block in medicinal chemistry for structure-activity relationship (SAR) studies.
• Precursor for the development of novel agrochemicals and pesticides.
• Key starting material in peptide mimetics and bio-conjugation chemistry.
• Research chemical for studying enzyme inhibition and receptor binding.
• Intermediate in the production of specialty fine chemicals and advanced materials.

Basic Information

Product Name	4-(Trifluoromethyl)-Dl-Phenylglycine
CAS No.	142012-65-5
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	DL-4-(Trifluoromethyl)phenylglycine; (±)-2-Amino-2-[4-(trifluoromethyl)phenyl]acetic acid; 4-(Trifluoromethyl)benzene glycine; α-Amino-4-(trifluoromethyl)benzeneacetic acid; 2-Amino-2-(4-trifluoromethylphenyl)acetic acid; (RS)-2-Amino-2-[4-(trifluoromethyl)phenyl]ethanoic acid; 4-TFM-Phe-OH (DL)
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)-Dl-Phenylglycine is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed specifications, including assay, chiral purity, and impurity profiles. Our quality commitment supports applications requiring high-purity intermediates for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (racemic)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.