Description

Verapamil Impurity A is a high-purity chemical reference standard, specifically identified as a known impurity of the calcium channel blocker Verapamil. This compound is critical for pharmaceutical research and development, enabling precise analytical method development, validation, and quality control of the active pharmaceutical ingredient. It is an essential material for analytical chemists and quality assurance professionals in the pharmaceutical industry, particularly those involved in ensuring drug safety, efficacy, and regulatory compliance for cardiovascular medications.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the identification and quantification of Verapamil Impurity A in drug substances and products.
• Analytical Method Development: Used to develop and optimize chromatographic methods, such as HPLC and UPLC, for impurity profiling.
• Quality Control & Assurance: Essential for routine batch testing in pharmaceutical manufacturing to monitor impurity levels against ICH guidelines.
• Regulatory Compliance & Filing: Supports the preparation of regulatory documentation (e.g., for FDA, EMA) by providing characterized impurity data for drug master files.
• Stability Studies: Employed to track the formation of this specific degradation product under various stress conditions.
• Pharmacopoeial Testing: Used in testing to meet the specifications of pharmacopoeias like USP, EP, and BP for Verapamil-related substances.

Basic Information

Product Name	Verapamil Impurity A
CAS No.	141991-88-0
Molecular Formula	C27H38N2O4
Molecular Weight	454.60 g/mol
Synonyms	5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile; Verapamil N-Desmethyl Impurity; Desmethylverapamil; Norverapamil; Verapamil Impurity 1; Verapamil Related Compound A; α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzenepropanenitrile
EINECS	Contact for details

Quality Control

Every batch of Verapamil Impurity A (CAS 141991-88-0) is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic techniques, to ensure compliance with industry standards for pharmaceutical impurities. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profile is provided with each shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C, in a dry environment. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.