Description

Human Des(1-6)Igf-Ii is a truncated, bioactive analog of Insulin-like Growth Factor II (IGF-II), a key peptide hormone involved in cell growth, development, and metabolism. This modified form, with the first six N-terminal amino acids removed, offers distinct biological properties and stability profiles for advanced research and development applications. It is essential for scientists and manufacturers in the pharmaceutical, biotechnology, and life science research sectors, particularly those focused on metabolic studies, cancer research, and the development of novel therapeutic agents.

Application

• Biomedical Research: Used as a critical reagent in studying cell proliferation, differentiation, and apoptosis signaling pathways.
• Drug Discovery & Development: Serves as a reference standard or active component in screening assays and pre-clinical studies for metabolic disorders and oncology.
• Cell Culture & Tissue Engineering: Employed to promote growth and maintain specific cell lines in vitro, particularly stem cells and specialized tissue cultures.
• Diagnostic Development: Utilized in the calibration and development of immunoassays (e.g., ELISA) to measure IGF-II and related biomarkers.
• Biochemical Studies: Applied in structural-activity relationship (SAR) studies to understand the functional domains of IGF-II.
• Peptide Synthesis & Conjugation: Acts as a starting material or template for the synthesis of more complex peptide conjugates and analogs.

Basic Information

Product Name	Human Des(1-6)Igf-Ii
CAS No.	141909-47-9
Molecular Formula	C390H620N112O115S6
Molecular Weight	8690.8 g/mol (approximately)
Synonyms	Des(1-6)IGF-II; IGF-II (7-67); Insulin-like Growth Factor II (7-67); Somatomedin A (7-67); Human IGF-II variant; Truncated IGF-II; [Des-1-6]-IGF-II; IGF-2 (7-67)
EINECS	Contact for details

Quality Control

Our Human Des(1-6)Igf-Ii is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and biological activity. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes data from HPLC, mass spectrometry, and amino acid analysis. Our quality commitment aligns with standards suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Biological Activity	Determined by cell-based proliferation assay (COA)
Endotoxin Level	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.