Description

(Z)-3-Amino-4,4,4-Trifluorocrotonic Acid Ethyl Ester is a versatile fluorinated building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity of its amino and trifluoromethyl-substituted crotonate ester groups, enabling the construction of complex, fluorine-containing heterocycles and pharmacophores. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated pyrimidines, pyridines, and other nitrogen-containing heterocycles with potential biological activity.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides where the trifluoromethyl group can improve lipophilicity and environmental stability.
• Material Science Precursor: Serves as a monomer or modifier in the synthesis of specialty polymers and advanced materials with unique surface properties.
• Fluorine Chemistry: An essential reagent for studying nucleophilic addition and cyclization reactions involving α,β-unsaturated esters with electron-withdrawing groups.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated analogs of natural products for mechanism-of-action studies.

Basic Information

Product Name	(Z)-3-Amino-4,4,4-Trifluorocrotonic Acid Ethyl Ester
CAS No.	141860-78-8
Molecular Formula	C6H8F3NO2
Molecular Weight	183.13 g/mol
Synonyms	Ethyl (Z)-3-amino-4,4,4-trifluorobut-2-enoate; Ethyl 3-Amino-4,4,4-trifluorocrotonate; (Z)-Ethyl 3-amino-4,4,4-trifluorobut-2-enoate; 4,4,4-Trifluoro-3-aminocrotonic Acid Ethyl Ester; 3-Amino-4,4,4-trifluorocrotonic Acid Ethyl Ester (Z-isomer); 2-Butenoic acid, 3-amino-4,4,4-trifluoro-, ethyl ester, (2Z)-; TFE-3A-EE
EINECS	Contact for details

Quality Control

Our (Z)-3-Amino-4,4,4-Trifluorocrotonic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and isomeric integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its properties as a fluoride/strong alkali and highly volatile compound, ensure containers are kept tightly sealed to prevent moisture ingress and evaporation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
(Z)-Isomer Content (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.