Description

2-(4-Isothiocyanatobenzyl)-6-Methyldiethylenetriaminepentaacetic Acid is a bifunctional chelating agent that combines a potent DTPA (diethylenetriaminepentaacetic acid) backbone with a reactive isothiocyanate group. This compound matters for its ability to form stable, covalent bonds with biomolecules while simultaneously chelating metal ions, enabling precise labeling and imaging applications. It is primarily needed by researchers and manufacturers in the fields of radiopharmaceuticals, molecular imaging, and targeted drug delivery systems.

Application

• Conjugation agent for labeling antibodies, peptides, and proteins with diagnostic or therapeutic radionuclides (e.g., 111In, 90Y, 177Lu).
• Critical intermediate in the synthesis of bifunctional chelators for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging probes.
• Development of targeted radiopharmaceuticals for oncology, enabling precise tumor localization and treatment.
• Preparation of metal-chelate complexes for use in in vitro diagnostics and immunoassays.
• Research tool in biochemistry and molecular biology for studying protein interactions and cellular trafficking via metal-based tags.
• Component in the formulation of kits for the convenient preparation of radiometal-labeled biomolecules.

Basic Information

Product Name	2-(4-Isothiocyanatobenzyl)-6-Methyldiethylenetriaminepentaacetic Acid
CAS No.	141849-44-7
Molecular Formula	C24H33N5O10S
Molecular Weight	583.61 g/mol
Synonyms	p-SCN-Bn-Me-DTPA; 2-(p-Isothiocyanatobenzyl)-6-methyl-DTPA; 6-Methyl-2-(4-isothiocyanatobenzyl)-diethylenetriaminepentaacetic acid; Me-DTPA-p-SCN; Bifunctional DTPA chelator; DTPA derivative isothiocyanate; 1-[2-[[5-[Carboxymethyl-[4-(isothiocyanatomethyl)phenyl]methylamino]pentyl]-(carboxymethyl)amino]ethyl]-N-(carboxymethyl)-N-(2-carboxyethyl)glycine
EINECS	Contact for details

Quality Control

Our 2-(4-Isothiocyanatobenzyl)-6-Methyldiethylenetriaminepentaacetic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to moisture, heat, or light should be avoided to maintain stability and reactivity. Keep container tightly sealed under an inert atmosphere when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.