Description

7-(2-(2-Aminothiazol-4-Yl)-2- (1-Carboxy-1-Methylethoxyimino)Acetamido)-3-(3-(5,6-Dihydroxybenzimidazol-1-Yl)Propen-1-Yl)-3-Cephem-4-Carboxylic Acid is a sophisticated cephalosporin derivative, representing a key advanced intermediate in the synthesis of modern β-lactam antibiotics. Its complex structure is engineered to enhance antibacterial spectrum and potency, particularly against resistant strains. This high-value compound is essential for pharmaceutical R&D and manufacturing, targeting developers of next-generation anti-infective therapies.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of novel cephalosporin antibiotics.
• Antibacterial Drug Development: Serves as a core scaffold for research into new agents with improved activity against Gram-positive and Gram-negative bacteria.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize pharmacokinetic and pharmacodynamic properties of β-lactam compounds.
• GMP Manufacturing: Supplied as a qualified intermediate for cGMP production of active pharmaceutical ingredients (APIs) in regulated markets.
• Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	7-(2-(2-Aminothiazol-4-Yl)-2- (1-Carboxy-1-Methylethoxyimino)Acetamido)-3-(3-(5,6-Dihydroxybenzimidazol-1-Yl)Propen-1-Yl)-3-Cephem-4-Carboxylic Acid
CAS No.	141777-20-0
Molecular Formula	C27H26N8O9S
Molecular Weight	638.61 g/mol
Synonyms	(6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-3-[(E)-3-(5,6-dihydroxy-1H-benzimidazol-1-yl)prop-1-en-1-yl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Cephalosporin Derivative 141777-20-0; 3-Cephem-4-carboxylic Acid Derivative; Advanced Cephalosporin Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and manufacturing applications. Quality is verified through comprehensive analytical methods including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support development with material suitable for use under GMP guidelines upon request and qualification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.