Description

6-Chloro-2'-Deoxyguanosine is a modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a crucial synthetic intermediate and building block for the creation of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in the synthesis of nucleoside-based prodrugs and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in the development of prodrugs targeting viral polymerases for diseases such as hepatitis and herpes.
• Oncology Research: Serves as a precursor for chemotherapeutic agents designed to inhibit DNA replication in cancer cells.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate nucleotide metabolism and DNA repair mechanisms.
• Prodrug Synthesis: Modified to create masked nucleoside prodrugs with improved bioavailability and targeted delivery.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	6-Chloro-2'-Deoxyguanosine
CAS No.	141771-78-0
Molecular Formula	C10H12ClN5O4
Molecular Weight	301.69 g/mol
Synonyms	6-Chloro-2'-deoxyguanosine; 2'-Deoxy-6-chloroguanosine; 6-Chloro-9-(2-deoxy-β-D-erythro-pentofuranosyl)guanine; 6-Cl-dG; 6-Chloro-2'-deoxyguanosine; 6-Chloro-2'-desoxyguanosine; 6-Chloro-2'-deoxy-guanosine; 6-Chloro-deoxyguanosine
EINECS	Contact for details

Quality Control

Our 6-Chloro-2'-Deoxyguanosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.