Description

Fmoc-n-(tert-Butyloxycarbonylmethyl)-Glycine CAS NO 141743-16-0 is a specialized, high-purity amino acid derivative designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise, side-chain protected building blocks to construct complex peptide sequences. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and CROs engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected amino acid building block for the sequential assembly of peptides.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for producing custom peptides and peptide fragments.
• Pharmaceutical Intermediate: An essential raw material in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation and Labeling: Facilitates the site-specific introduction of functional groups or labels onto peptides for diagnostic or research applications.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic and Industrial Research: Supports fundamental studies in biochemistry, medicinal chemistry, and structural biology.

Basic Information

Product Name	Fmoc-n-(tert-Butyloxycarbonylmethyl)-Glycine
CAS No.	141743-16-0
Molecular Formula	C₂₃H₂₅NO₇
Molecular Weight	427.45 g/mol
Synonyms	Fmoc-N-Boc-Gly-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-[(1,1-dimethylethoxy)carbonylmethyl]glycine; Fmoc-N-(Boc-aminoethyl)-Glycine; Fmoc-N-(tert-Butoxycarbonylmethyl)glycine; N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-N-{[(tert-butoxy)carbonyl]methyl}glycine; N-Fmoc-N-(Boc-methyl)glycine; Boc-AEEA-Fmoc (Glycine derivative); (2-{[(9H-Fluoren-9-ylmethoxy)carbonyl][(tert-butoxycarbonyl)methyl]amino}acetic acid)
EINECS	Contact for details

Quality Control

Our Fmoc-n-(tert-Butyloxycarbonylmethyl)-Glycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.