Description

Deferiprone 3-o--D-Glucuronide is a specific glucuronide metabolite of the iron chelator deferiprone. This compound is of significant value in pharmaceutical research and development, particularly for metabolic and pharmacokinetic studies. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug metabolism, toxicology, and analytical method development for iron chelation therapies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification of deferiprone metabolites in biological matrices during clinical trials.
• Metabolite Identification & Profiling: Critical for in vitro and in vivo ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the metabolic pathway of deferiprone.
• Bioanalytical Method Development: Serves as a key analyte for developing and validating sensitive HPLC-MS/MS or LC-UV methods for pharmacokinetic analysis.
• Toxicology and Safety Assessment: Employed in studies to assess the safety profile and potential biological activity of deferiprone's major metabolites.
• Impurity Characterization: Used to identify and control glucuronide-related impurities in deferiprone active pharmaceutical ingredient (API) batches.
• Enzyme Kinetic Studies: Applied in research to investigate the kinetics of UDP-glucuronosyltransferase (UGT) enzymes responsible for its formation.

Basic Information

Product Name	Deferiprone 3-o--D-Glucuronide
CAS No.	141675-48-1
Molecular Formula	C12H17NO9
Molecular Weight	319.26 g/mol
Synonyms	Deferiprone Glucuronide; 1,2-Dimethyl-3-hydroxypyridin-4-one 3-O-β-D-Glucuronide; 3-Hydroxy-1,2-dimethyl-4(1H)-pyridinone 3-β-D-Glucuronide; L1 3-O-Glucuronide; CP20 3-O-Glucuronide; Deferiprone-3-Glucuronide; 3-Hydroxy-1,2-dimethylpyridin-4(1H)-one 3-O-β-D-glucopyranosiduronic acid
EINECS	Contact for details

Quality Control

Our Deferiprone 3-o--D-Glucuronide is manufactured under strict quality control protocols suitable for research and reference standard applications. Each batch is analyzed to ensure high purity and identity confirmation. Certificates of Analysis (COA) containing detailed results from HPLC, NMR, and MS are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.