Description

(4S)-4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-2-Pyrrolidinone is a high-value, chiral silyl-protected pyrrolidinone derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a protected chiral hydroxyl group, enabling stereoselective reactions essential for constructing complex molecules. This compound is particularly vital for pharmaceutical R&D and production, where it is used in the synthesis of active pharmaceutical ingredients (APIs), nucleosides, and other fine chemicals requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, particularly for antiviral and anticancer agents.
• Nucleoside & Nucleotide Chemistry: Used in the preparation of modified nucleosides and nucleotides for medicinal chemistry and biochemical research.
• Asymmetric Synthesis: Employed as a chiral auxiliary or protected intermediate in stereoselective carbon-carbon and carbon-heteroatom bond-forming reactions.
• Peptidomimetics & Proline Derivatives: Serves as a precursor for synthesizing modified amino acids and peptidomimetic scaffolds.
• Agrochemical Synthesis: Utilized in the development of chiral active ingredients for crop protection products.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Product Name	(4S)-4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-2-Pyrrolidinone
CAS No.	141629-19-8
Molecular Formula	C11H23NO2Si
Molecular Weight	229.39 g/mol
Synonyms	(4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-pyrrolidinone; (S)-4-((tert-Butyldimethylsilyl)oxy)pyrrolidin-2-one; 4-[(tert-Butyldimethylsilyl)oxy]-L-proline lactam; TBDMS-protected 4-hydroxy-2-pyrrolidinone (S-isomer); (S)-4-(tert-Butyldimethylsiloxy)-2-pyrrolidinone; (S)-N-Boc-4-(TBDMSO)-2-pyrrolidinone (related derivative); 4-TBDMSO-2-pyrrolidinone (S)
EINECS	Contact for details

Quality Control

Our (4S)-4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-2-Pyrrolidinone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive analytical data, including chiral purity (enantiomeric excess) and standard impurity profiles via HPLC, GC, and NMR. Certificates of Analysis (COA) detailing identity, purity, and specific tests are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (Enantiomeric Excess)	≥98.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.