Description

5-(Trifluoromethyl)-2-Pyrrolidinone is a high-value, fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl group, which imparts desirable properties like enhanced metabolic stability and lipophilicity to target molecules, making it a critical intermediate in modern chemical development. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to incorporate fluorine into novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in CNS and oncology research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity.
• Ligand and Catalyst Development: Serves as a precursor for specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Employed in the synthesis of fluorinated polymers and advanced organic electronic materials.
• Chemical Research & Development: A versatile building block for medicinal chemistry and process chemistry in both academic and industrial R&D settings.
• Fluorine-Containing Compound Library: Used in combinatorial chemistry for the generation of diverse compound libraries for high-throughput screening.

Basic Information

Product Name	5-(Trifluoromethyl)-2-Pyrrolidinone
CAS No.	141519-28-0
Molecular Formula	C5H6F3NO
Molecular Weight	153.10 g/mol
Synonyms	5-(Trifluoromethyl)pyrrolidin-2-one; 2-Pyrrolidinone, 5-(trifluoromethyl)-; 5-Trifluoromethyl-2-pyrrolidinone; 5-Trifluoromethylpyrrolidin-2-one; α-(Trifluoromethyl)-γ-butyrolactam; 1,2,3,6-Tetrahydro-5-(trifluoromethyl)-2H-pyrrol-2-one
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-2-Pyrrolidinone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment supports applications requiring reliable and traceable raw materials for GMP and non-GMP development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C for long-term stability. Allow the container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.