Description

Cyclobutanecarbonitrile, 3-Acetyl-2,2-Dimethyl-, cis- (9Ci) is a high-purity, specialized organic nitrile building block with a defined stereochemistry. This compound is valued for its unique sterically hindered structure, which makes it a critical intermediate in advanced synthetic chemistry. It is primarily sought after by research institutions and pharmaceutical companies for the development of novel active pharmaceutical ingredients (APIs) and complex agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging its nitrile functionality and rigid cyclobutane core.
• Material Science: Serves as a precursor for specialty polymers and liquid crystals, where its structural rigidity can impart desired thermal and optical properties.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex natural product analogs and exploring new chemical spaces in medicinal chemistry.
• Catalyst Ligand Synthesis: The nitrile and ketone groups provide handles for modification into novel ligands for asymmetric catalysis.

Basic Information

Item	Details
Product Name	Cyclobutanecarbonitrile, 3-Acetyl-2,2-Dimethyl-, cis- (9Ci)
CAS No.	141422-97-1
Molecular Formula	C9H13NO
Molecular Weight	151.21 g/mol
Synonyms	cis-3-Acetyl-2,2-dimethylcyclobutanecarbonitrile; (1S,3R)-3-Acetyl-2,2-dimethylcyclobutanecarbonitrile; 2,2-Dimethyl-3-oxocyclobutanecarbonitrile (related); 3-Acetyl-2,2-dimethylcyclobutanecarbonitrile; cis-3-Acetyl-2,2-dimethyl-1-cyanocyclobutane; Cyclobutanecarbonitrile, 3-acetyl-2,2-dimethyl-, cis-; 141422-97-1
EINECS	Contact for details

Quality Control

Every batch of Cyclobutanecarbonitrile, 3-Acetyl-2,2-Dimethyl-, cis- (9Ci) is produced under strict quality management protocols. We provide comprehensive analytical data to ensure identity, purity, and consistency, which is critical for your sensitive downstream reactions. A Certificate of Analysis (COA) detailing purity (typically by GC/HPLC), chiral purity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% cis-isomer
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.