Description

2-Fluoro-2-Deoxy-Glucose Tetraacetate is a key fluorinated carbohydrate derivative and a crucial protected intermediate in radiopharmaceutical synthesis. This compound matters because it serves as the direct precursor for the production of [18F]FDG, the most widely used radiotracer in Positron Emission Tomography (PET) for oncology, neurology, and cardiology diagnostics. Pharmaceutical manufacturers, radiopharmaceutical synthesis facilities, and advanced research institutions in life sciences require this high-purity intermediate to ensure reliable and efficient production of clinical-grade PET imaging agents.

Application

• Radiopharmaceutical Synthesis: Primary use as the precursor for the radiosynthesis of Fluorodeoxyglucose ([18F]FDG) via nucleophilic fluorination and subsequent deprotection.
• PET Tracer Production: Essential raw material in automated synthesis modules (e.g., GE TRACERlab, Siemens Explora) for the routine manufacturing of clinical PET doses.
• Oncology Research: Used in the development and study of novel fluorinated glucose analogs for targeting tumor metabolism.
• Neurological Disorder Diagnostics: Enables the production of [18F]FDG for imaging brain glucose metabolism in Alzheimer's disease, epilepsy, and other neurological conditions.
• Cardiac PET Imaging: Supports the creation of diagnostic agents for assessing myocardial viability and inflammation.
• Academic & Preclinical Research: Serves as a critical starting material in chemical and biochemical laboratories for synthesizing fluorinated sugar probes and metabolic inhibitors.
• Process Development & Scale-Up: Used by CROs and CDMOs to develop and optimize robust, GMP-compliant synthesis pathways for regulatory filings.

Basic Information

Product Name	2-Fluoro-2-Deoxy-Glucose Tetraacetate
CAS No.	141395-48-4
Molecular Formula	C14H19FO9
Molecular Weight	350.29 g/mol
Synonyms	1,3,4,6-Tetra-O-acetyl-2-deoxy-2-fluoro-D-glucopyranose; 2-FDG Tetraacetate; 2-Deoxy-2-fluoro-D-glucose tetraacetate; FDG Tetraacetate Precursor; 2-Fluoro-2-deoxy-D-glucose 1,3,4,6-tetraacetate; Tetraacetyl-2-fluoro-2-deoxyglucose; Precursor for [18F]FDG; 2-FDGTA
EINECS	Contact for details

Quality Control

We supply 2-Fluoro-2-Deoxy-Glucose Tetraacetate manufactured under strict quality systems suitable for radiopharmaceutical applications. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical and isomeric purity critical for efficient radiolabeling. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing identity, purity, and impurity profiles. We support development and commercial needs with material traceable to GMP and ISO quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent hydrolysis of the acetyl protecting groups. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Isomeric Purity (by HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.