Description

Cyclohexanecarbonitrile, 4-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]- is a high-value, protected synthetic intermediate of significant importance in advanced organic synthesis. This compound is specifically engineered to provide a protected hydroxyl functionality on a cyclohexane backbone, enabling complex multi-step reactions with high selectivity and yield. It is a critical building block for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to construct sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing functionalized cyclohexyl moieties.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require stereochemically defined cyclohexane derivatives.
• Advanced Material Precursor: Serves as a monomer or intermediate in the synthesis of specialty polymers and liquid crystals with tailored properties.
• Organic Synthesis Research: Employed in academic and industrial R&D laboratories for methodology development, including studies on silyl ether protection/deprotection strategies and nitrile transformations.
• Chiral Synthesis: Potential use in the preparation of enantiomerically pure compounds, given the prochirality of the cyclohexane ring, for applications in asymmetric catalysis.
• Peptidomimetics & Bioactive Molecule Development: The nitrile and protected alcohol groups make it a versatile scaffold for designing enzyme inhibitors and other bioactive molecules.

Basic Information

Product Name	Cyclohexanecarbonitrile, 4-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]-
CAS No.	141336-97-2
Molecular Formula	C23H29NOSi
Molecular Weight	363.57 g/mol
Synonyms	4-[(tert-Butyldiphenylsilyl)oxy]cyclohexanecarbonitrile; 4-(tert-Butyldiphenylsiloxy)cyclohexanecarbonitrile; 4-(TBDPSO)Cyclohexanecarbonitrile; 4-(tert-Butyldiphenylsilyloxy)cyclohexanecarbonitrile; 4-(Tert-butyldiphenylsilyloxy)cyclohexyl cyanide; 4-Cyano-1-[(tert-butyldiphenylsilyl)oxy]cyclohexane; 1-Cyano-4-(tert-butyldiphenylsiloxy)cyclohexane; TBDPS-protected 4-hydroxycyclohexanecarbonitrile
EINECS	Contact for details

Quality Control

Our Cyclohexanecarbonitrile, 4-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]- is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in cGMP-compliant pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.