Description

Toxin 2, Centruroides Noxius CAS NO 141322-33-0 is a highly purified, biologically active peptide toxin derived from the venom of the Mexican scorpion *Centruroides noxius*. This compound is a critical research tool for studying voltage-gated sodium (Nav) channels, particularly the Nav1.1 subtype, due to its potent and selective binding properties. It is essential for neuroscience, pharmacology, and toxicology research, enabling the development of novel therapeutic agents and diagnostic tools for neurological disorders and pain management.

Application

• Neuroscience Research: As a selective modulator of voltage-gated sodium channels (Nav1.1), it is used to investigate channel function, neuronal excitability, and signal transduction pathways.
• Pharmacological Studies: Serves as a reference standard and active agent in high-throughput screening (HTS) for the discovery of new analgesics, anticonvulsants, and neuroprotective drugs.
• Toxicology & Venom Research: Used in comparative studies of scorpion venom components and for the development of next-generation antivenoms and detection assays.
• Ion Channel Characterization: A key reagent for patch-clamp electrophysiology and binding assays to characterize subtype specificity and kinetics of Nav channels.
• Biomarker Development: Employed in the research and development of diagnostic biomarkers for conditions linked to sodium channel dysfunction.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in cellular and molecular biology.

Basic Information

Product Name	Toxin 2, Centruroides Noxius
CAS No.	141322-33-0
Molecular Formula	C254H386N70O75S7 (Approx.)
Molecular Weight	~ 5850 Da (Approx.)
Synonyms	Cn2 Toxin; Centruroides noxius Toxin 2; Nav1.1 Channel Toxin; β-toxin Cn2; Scorpion Toxin Cn2; Neurotoxin Cn2; Voltage-Gated Sodium Channel Toxin 2; CAS 141322-33-0
EINECS	Contact for details

Quality Control

Our Toxin 2, Centruroides Noxius is produced and analyzed under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, potency, and sterility data. We adhere to GLP (Good Laboratory Practice) standards, and our quality system is designed to meet the rigorous demands of global academic and pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store frozen at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Functional Activity)	≥ 98%
Endotoxin Level (LAL)	< 1.0 EU/mg
Moisture Content (KF)	< 5.0%
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.