Description

Alfa-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-Benzenacetic Acid Methyl Ester is a high-purity, protected amino acid derivative widely used as a critical building block in advanced organic synthesis. Its primary value lies in providing a versatile and reactive scaffold for constructing complex peptide and pharmaceutical intermediates under controlled conditions. This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality raw materials for API synthesis and novel compound development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptide-based drugs and enzyme inhibitors.
• Peptide Synthesis: Serves as a protected amino acid ester building block in solid-phase and solution-phase peptide synthesis (SPPS).
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators that incorporate amino acid motifs.
• Bioconjugation Chemistry: Employed in the preparation of linkers and spacers for antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Probes: Acts as a starting material for synthesizing labeled compounds and probes used in biochemical assays and diagnostic research.
• Custom Synthesis: A versatile reagent for contract research organizations (CROs) and CDMOs engaged in custom synthesis and process development projects.

Basic Information

Product Name	Alfa-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-Benzenacetic Acid Methyl Ester
CAS No.	141190-94-5
Molecular Formula	C15H21NO4
Molecular Weight	279.33 g/mol
Synonyms	Methyl 2-((tert-butoxycarbonyl)amino)-2-phenylacetate; Boc-Phenylglycine methyl ester; Boc-Phg-OMe; N-Boc-2-phenylglycine methyl ester; (tert-Butoxycarbonylamino)(phenyl)acetic acid methyl ester; 2-[(tert-Butoxycarbonyl)amino]-2-phenylacetic acid methyl ester; N-(tert-Butoxycarbonyl)-2-phenylglycine methyl ester; Boc-Phenylglycine-OMe
EINECS	Contact for details

Quality Control

Our Alfa-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-Benzenacetic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for demanding pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants and maintaining an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.