Description

Alpha1-Antichymotrypsin, Human is a high-purity, naturally occurring serine protease inhibitor (serpin) that plays a critical role in regulating inflammatory and proteolytic processes. This glycoprotein is essential for research and development in life sciences, offering a key reagent for studying protease inhibition, inflammatory pathways, and disease mechanisms. It is primarily utilized by biotechnology firms, pharmaceutical R&D departments, and diagnostic manufacturers focused on areas such as chronic obstructive pulmonary disease (COPD), Alzheimer's disease, and other conditions involving tissue remodeling and inflammation.

Application

• Biochemical Research: Used as a standard or inhibitor in enzymatic assays to study chymotrypsin-like serine proteases and inflammatory cascades.
• Diagnostic Development: Serves as a critical antigen or calibrator in the production of immunoassays (ELISA, Western Blot) for detecting ACT levels in human serum, relevant for clinical diagnostics.
• Pharmaceutical R&D: Employed in drug discovery programs targeting protease dysregulation, particularly for neurological and pulmonary diseases.
• Cell Culture & Tissue Engineering: Acts as a supplement in specialized media to modulate protease activity and study its effects on cell behavior and extracellular matrix stability.
• Proteomics: Utilized as a tool protein for interaction studies, protein complex analysis, and biomarker discovery related to the serpin family.

Basic Information

Product Name	Alpha1-Antichymotrypsin, Human
CAS No.	141176-92-3
Molecular Formula	CnHmNoOpSq (Contact for details)
Molecular Weight	~68 kDa (Glycoprotein)
Synonyms	ACT; AACT; α-1-Antichymotrypsin; Serpin A3; SERPINA3; Protease Inhibitor, Antichymotrypsin; Human α-1-Antichymotrypsin; ACT Human; A1AC
EINECS	Contact for details

Quality Control

Our Alpha1-Antichymotrypsin, Human is produced and tested under strict quality management systems. Each lot undergoes rigorous analysis to ensure identity, purity, and functional activity, meeting the exacting standards required for research and in-vitro diagnostic use. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications such as purity (by SDS-PAGE and HPLC), biological activity, endotoxin levels, and absence of contaminating proteases.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. Aliquot upon receipt for optimal preservation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Immunological)	Complies
Purity (SDS-PAGE)	> 95%
Purity (HPLC)	> 98%
Biological Activity	Fully active (Contact for details)
Endotoxin	< 1.0 EU/mg
Protein Content (Biuret)	> 90%
Solubility	Soluble in water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.