Description

Zileuton β-D-Glucuronide is a major, pharmacologically relevant metabolite of the leukotriene biosynthesis inhibitor Zileuton. This compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It serves as a vital reference standard for scientists and quality control laboratories in the pharmaceutical and biotechnology sectors, ensuring accurate quantification and characterization of Zileuton and its metabolic pathways.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the calibration of analytical instruments and validation of bioanalytical methods.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic fate, bioavailability, and excretion profile of Zileuton in preclinical and clinical research.
• Impurity Profiling and Control: Used to identify, quantify, and monitor this specific glucuronide conjugate as a potential impurity in Zileuton active pharmaceutical ingredient (API) batches.
• Bioequivalence Testing: Critical for developing assays to compare metabolite levels between different drug formulations.
• Toxicological Research: Employed in studies to understand the safety and toxicity profile associated with Zileuton's metabolic products.
• Academic and Contract Research: A key reagent for universities and CROs (Contract Research Organizations) conducting fundamental research on eicosanoid biology and inflammation pathways.

Basic Information

Product Name	Zileuton β-D-Glucuronide
CAS No.	141056-63-5
Molecular Formula	C23H29N3O8S
Molecular Weight	507.56 g/mol
Synonyms	N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)urea β-D-Glucopyranosiduronic Acid; Zileuton Glucuronide; Zileuton β-D-Glucuronide; ABT-077 Glucuronide; (±)-N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea β-D-Glucopyranosiduronic Acid; Zileuton O-β-D-Glucuronide; (RS)-Zileuton β-D-Glucuronide
EINECS	Contact for details

Quality Control

Every batch of Zileuton β-D-Glucuronide is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical documentation, including a Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profiles. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and regulatory submission support.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.