Description

8-Hydroxy Mianserin B-D-Glucuronide is a key metabolite of the antidepressant drug mianserin, formed via the glucuronidation pathway. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It serves as a critical reference standard for laboratories in the pharmaceutical, contract research organization (CRO), and academic sectors requiring high-purity materials for analytical and metabolic studies.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for quantitative and qualitative analysis in drug development.
• Metabolite Identification & Profiling: Essential for in vitro and in vivo studies to map the metabolic pathways of Mianserin.
• Bioanalytical Method Development: Used to develop and validate sensitive HPLC, LC-MS, or LC-MS/MS methods for pharmacokinetic studies.
• DMPK (Drug Metabolism and Pharmacokinetics) Research: Critical for understanding the absorption, distribution, metabolism, and excretion (ADME) properties of the parent drug.
• Clinical Toxicology & Forensic Analysis: Serves as a marker in assays designed for therapeutic drug monitoring or forensic investigations.
• Enzyme Activity Studies: Used as a substrate to study the activity of UDP-glucuronosyltransferase (UGT) enzymes.

Basic Information

Product Name	8-Hydroxy Mianserin B-D-Glucuronide
CAS No.	140695-49-4
Molecular Formula	C26H33N3O8
Molecular Weight	515.56 g/mol
Synonyms	8-Hydroxymianserin Glucuronide; 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin-8-ol β-D-Glucopyranosiduronic Acid; Mianserin Metabolite 8-Hydroxy Glucuronide; 8-OH-Mianserin Glucuronide; 8-Hydroxy Mianserin β-D-Glucuronide; 8-Hydroxy Mianserin Glucuronide Conjugate
EINECS	Contact for details

Quality Control

Our 8-Hydroxy Mianserin B-D-Glucuronide is manufactured under strict quality control protocols suitable for research and analytical applications. Each batch is characterized using advanced spectroscopic and chromatographic techniques to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, assay results, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with client requirements for method validation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0% (Area Percent)
Assay (HPLC)	≥90.0% (on dried basis)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.