Description

Guanylin is a bioactive peptide hormone that plays a critical role in regulating intestinal fluid and electrolyte homeostasis. This compound is of significant interest for its function as an endogenous ligand for guanylyl cyclase C (GC-C) receptors. It is primarily utilized in advanced pharmaceutical research and biochemical studies focused on gastrointestinal physiology, secretory diarrhea, and as a reference standard in analytical laboratories.

Application

• Biomedical Research: Used as a critical tool in studying the guanylin/guanylyl cyclase-C signaling pathway and its role in intestinal secretion and mucosal function.
• Drug Discovery & Development: Serves as a reference compound and a lead structure for developing novel therapeutics targeting secretory diarrhea, constipation-predominant irritable bowel syndrome (IBS-C), and colorectal cancer.
• In Vitro & In Vivo Studies: Employed in cell-based assays and animal models to investigate fluid balance, electrolyte transport, and epithelial cell biology.
• Diagnostic & Analytical Standards: Used as a high-purity calibrant and reference material in mass spectrometry, HPLC, and immunoassay development for quantitative analysis.
• Peptide Chemistry: Acts as a model peptide in studies of peptide synthesis, stability, structure-activity relationships (SAR), and formulation science.

Basic Information

Product Name	Guanylin
CAS No.	140653-38-9
Molecular Formula	C53H74N18O19S4
Molecular Weight	1363.5 g/mol
Synonyms	Guanylin (human); Guanylin-15; Preproguanylin (101-115); Guanylin Peptide; H-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-NH2 (disulfide bridges: Cys3-Cys12, Cys6-Cys15); ST Peptide; Ligand for Guanylate Cyclase C.
EINECS	Contact for details

Quality Control

Our Guanylin is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.