Description

4-Iodonaphthalene-1-Carbonitrile is a high-purity, multi-functional aromatic building block essential for advanced organic synthesis. This compound matters for its unique molecular architecture, combining an iodine substituent and a nitrile group on a naphthalene core, enabling precise cross-coupling reactions and functional group transformations. It is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for developing novel active ingredients and functional organic materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly for oncology and central nervous system (CNS) targets.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators requiring specific halogenated aromatic structures.
• Material Science: A valuable monomer or building block for creating organic semiconductors, liquid crystals, and advanced polymers with tailored electronic properties.
• Cross-Coupling Reactions: The iodine atom is an excellent leaving group for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to construct complex biaryl systems.
• Nitrile Functionalization: The cyano group can be hydrolyzed to carboxylic acids, reduced to amines, or used to form heterocycles like tetrazoles, expanding molecular diversity.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorescent Probe Development: The naphthalene scaffold makes it suitable for creating fluorescent tags and sensors for biochemical applications.

Basic Information

Product Name	4-Iodonaphthalene-1-Carbonitrile
CAS No.	140456-96-8
Molecular Formula	C11H6IN
Molecular Weight	279.08 g/mol
Synonyms	1-Cyano-4-iodonaphthalene; 4-Iodo-1-naphthalenecarbonitrile; 1-Naphthalenecarbonitrile, 4-iodo-; 4-Iodonaphthalene-1-carbonitrile; Naphthalene-1-carbonitrile, 4-iodo-; 4-Iodo-1-cyanonaphthalene; 4-Iodo-1-naphthonitrile
EINECS	Contact for details

Quality Control

Our 4-Iodonaphthalene-1-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment to guarantee batch-to-batch consistency and support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere for prolonged manipulations to ensure long-term stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.