Description

Human Pai-1 CAS NO 140208-23-7 is a high-purity biochemical reagent, specifically the human plasminogen activator inhibitor-1 (PAI-1), a key serine protease inhibitor (serpin) involved in regulating fibrinolysis and cell migration. This compound is essential for researchers and developers in life sciences, providing a critical tool for studying thrombosis, fibrosis, and various cardiovascular and oncological pathways. It is primarily utilized by biotechnology firms, pharmaceutical R&D departments, and academic research institutions focused on hemostasis, tissue remodeling, and drug discovery.

Application

• Biomedical Research: Fundamental studies on the role of PAI-1 in fibrinolysis, cell adhesion, and signaling pathways.
• Drug Discovery & Development: Screening and validation of novel therapeutic candidates targeting PAI-1 for conditions like thrombosis, fibrosis, and cancer.
• Diagnostic Assay Development: Used as a standard or critical component in the development of ELISA kits and other immunoassays to measure PAI-1 levels in clinical samples.
• Cell Culture & In Vitro Studies: Investigation of cellular processes such as angiogenesis, tumor cell invasion, and extracellular matrix degradation.
• Enzyme Kinetics: Serves as a specific inhibitor in kinetic studies of tissue-type and urokinase-type plasminogen activators (tPA/uPA).
• Quality Control & Standardization: Acts as a reference standard for the quality control of related diagnostic reagents and biopharmaceutical products.

Basic Information

Product Name	Human Pai-1
CAS No.	140208-23-7
Molecular Formula	Contact for details
Molecular Weight	~45 kDa (approx.)
Synonyms	Plasminogen Activator Inhibitor 1, PAI-1, Serpin E1, Endothelial Plasminogen Activator Inhibitor, PLANH1, PAI, PAI1
EINECS	Contact for details

Quality Control

Our Human Pai-1 is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous quality testing, including purity analysis by SDS-PAGE and HPLC, functional activity assays, and endotoxin level checks. Certificates of Analysis (COA) detailing specific results for purity, activity, and concentration are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (SDS-PAGE)	> 95%
Identification (Western Blot)	Positive for Human PAI-1
Biological Activity	Contact for details
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.