Description

(S)-Ketoprofen Acyl-β-D-Glucuronide is a key metabolite and reference standard of the non-steroidal anti-inflammatory drug (NSAID) (S)-Ketoprofen. This compound is essential for advanced pharmacokinetic and metabolic studies, providing critical insights into drug clearance pathways and bioanalytical method development. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug metabolism, toxicology, and analytical chemistry.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification of (S)-Ketoprofen and its metabolites in biological matrices using HPLC, LC-MS, and GC-MS.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Critical for investigating the Phase II glucuronidation metabolic pathway, understanding excretion profiles, and assessing drug-drug interaction potentials.
• Bioanalytical Method Development and Validation: Used as a calibrator and quality control sample to develop, validate, and ensure the accuracy and precision of analytical assays in compliance with GLP and FDA/EMA guidelines.
• Toxicology and Safety Assessment: Employed in studies to characterize metabolite profiles and evaluate the safety of the parent drug compound.
• Academic and Clinical Research: Supports fundamental research on NSAID metabolism, stereoselective pharmacokinetics, and the role of acyl glucuronides in pharmacology.

Basic Information

Product Name	(S)-Ketoprofen Acyl-β-D-Glucuronide
CAS No.	140148-26-1
Molecular Formula	C25H26O10
Molecular Weight	486.47 g/mol
Synonyms	(S)-Ketoprofen 1-O-β-Acyl Glucuronide; Dexketoprofen Acyl Glucuronide; (2S)-2-(3-Benzoylphenyl)propanoic acid β-D-glucopyranosiduronic acid; Dexketoprofen Glucuronide; S-Ketoprofen Glucuronide; (S)-Ketoprofen β-D-Glucuronide; Acyl Glucuronide of Dexketoprofen
EINECS	Contact for details

Quality Control

Our (S)-Ketoprofen Acyl-β-D-Glucuronide is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, with testing performed via validated methods including HPLC and NMR. We support research conducted under GMP/GLP compliance frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.