Description

(R)-Ketoprofen Acyl-β-D-Glucuronide is a specific, high-purity metabolite of the non-steroidal anti-inflammatory drug (NSAID) ketoprofen. This compound is of critical importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily required by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in bioanalytical method development and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of ketoprofen metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, clearance rates, and bioavailability of ketoprofen in preclinical and clinical research.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC-MS/MS or LC-UV methods for therapeutic drug monitoring and toxicology studies.
• Impurity Profiling: Acts as a key impurity standard in the quality control of ketoprofen active pharmaceutical ingredient (API) to ensure product safety and efficacy.
• Enantiomeric Specificity Research: Facilitates studies focused on the stereoselective metabolism and activity of the (R)-enantiomer of ketoprofen.

Basic Information

Product Name	(R)-Ketoprofen Acyl-β-D-Glucuronide
CAS No.	140148-25-0
Molecular Formula	C25H26O10
Molecular Weight	486.47 g/mol
Synonyms	(R)-Ketoprofen Glucuronide; (R)-Ketoprofen Acyl Glucuronide; (2R)-2-[3-(Benzoyl)phenyl]propanoic acid β-D-glucopyranosiduronic acid; Ketoprofen (R enantiomer) Acyl-β-D-Glucuronide; (R)-Ketoprofen 1-O-β-Acylglucuronide; (R)-KP-AG; (R)-Ketoprofen β-D-Glucuronide Ester
EINECS	Contact for details

Quality Control

Our (R)-Ketoprofen Acyl-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and reference materials. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results for purity, impurities, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.