Description

N''-α-(tert-Butoxycarbonyl)-n-Methoxy-n-Methyl-N''-ω-Nitro-L-Argininamide is a protected arginine derivative, a crucial building block in advanced peptide synthesis. This compound is specifically engineered to provide orthogonal protection for the guanidino group, enabling precise and efficient construction of complex peptide sequences. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the controlled incorporation of arginine residues into peptide chains.
• Pharmaceutical R&D: Serves as a critical intermediate in the synthesis of peptide-based drug candidates targeting various diseases.
• Bioconjugation: Used in the preparation of peptide-protein conjugates, antibody-drug conjugates (ADCs), and other bioconjugates where a selectively deprotectable arginine is required.
• Peptidomimetic Design: Enables the creation of modified peptide structures with enhanced stability, bioavailability, or receptor affinity.
• Biochemical Research: Employed in the study of enzyme-substrate interactions, signal transduction pathways, and protein-protein interactions involving arginine.
• Custom Peptide Services: A fundamental raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	N''-α-(tert-Butoxycarbonyl)-n-Methoxy-n-Methyl-N''-ω-Nitro-L-Argininamide
CAS No.	139976-34-4
Molecular Formula	C15H30N6O6
Molecular Weight	390.44 g/mol
Synonyms	Boc-Arg(NO2)-N(OMe)Me; Nα-Boc-Nω-nitro-L-arginine N-methyl-N-methoxyamide; Boc-Nω-nitro-L-arginine methylamide methyl ester; tert-Butyl N-[(2S)-5-[(N'-methoxy-N'-methylcarbamimidoyl)amino]-1-(nitroamino)-1-oxopentan-2-yl]carbamate; L-Argininamide, N2-[(1,1-dimethylethoxy)carbonyl]-N5-(methoxymethylideneamino)-N1-nitro-; Protected L-Arginine derivative; Boc-Arg(NO2)-NHOMe
EINECS	Contact for details

Quality Control

Our production of this high-purity peptide intermediate adheres to stringent quality protocols. Every batch is characterized and tested to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as assay (HPLC), chiral purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.