Description

4-Fluoro-2-Methylphenylboronic Acid is a versatile and high-value organoboron building block essential for modern synthetic chemistry. Its primary value lies in enabling the efficient construction of complex molecular architectures through the widely used Suzuki-Miyaura cross-coupling reaction. This compound is particularly critical for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to introduce the 4-fluoro-2-methylphenyl moiety into target molecules, a key structural feature in active ingredients. Its reliable performance makes it a staple in R&D laboratories and scale-up production facilities globally.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring a fluorinated aromatic system for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atom often improves biological activity and environmental persistence.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, liquid crystals, and polymers with tailored properties.
• Suzuki-Miyaura Cross-Coupling: The principal application is as a boron reagent in palladium-catalyzed cross-coupling reactions with organic halides to form biaryl and other carbon-carbon bonds.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry for the rapid generation of diverse compound libraries for drug discovery screening.
• Ligand and Catalyst Preparation: Useful in the synthesis of specialized ligands for catalysis or as a component in metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Fluoro-2-Methylphenylboronic Acid
CAS No.	139911-29-8
Molecular Formula	C7H8BFO2
Molecular Weight	153.95 g/mol
Synonyms	(4-Fluoro-2-methylphenyl)boronic acid; 2-Methyl-4-fluorophenylboronic acid; 4-Fluoro-o-tolylboronic acid; Boronic acid, B-(4-fluoro-2-methylphenyl)-; 4-Fluoro-2-methylbenzeneboronic acid; 139911-29-8; 4-Fluoro-2-methylphenylboronic acid pinacol ester (common derivative)
EINECS	Contact for details

Quality Control

Every batch of our 4-Fluoro-2-Methylphenylboronic Acid is produced and tested under a strict quality management system. We guarantee high purity and consistency to meet the exacting standards of research and industrial synthesis. Comprehensive analytical testing, including HPLC, NMR, and elemental analysis, is performed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to ensure full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.