Description

D-Threo-1-Phenyl-2-Hexadecanoylamino-3-Morpholino-1-Propanol Hcl is a high-purity synthetic organic compound belonging to the class of ceramide analogs and glycosyltransferase inhibitors. This compound is a critical research-grade intermediate and reference standard for investigating sphingolipid metabolism and its role in cellular processes. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on developing novel therapeutics for metabolic disorders, cancer, and neurological diseases.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate and reference standard in the synthesis and study of glucosylceramide synthase (GCS) inhibitors.
• Biochemical Research: Used as a potent inhibitor in studies of sphingolipid biosynthesis and metabolism pathways.
• Oncology Research: Investigated for its potential role in modulating ceramide-related apoptosis and overcoming multidrug resistance in cancer cell lines.
• Metabolic Disorder Studies: Applied in research models for diseases like Gaucher's disease, where glycosphingolipid accumulation is a key factor.
• Neuroscience Research: Utilized to explore the function of sphingolipids in neuronal cell signaling and survival.
• Reference Standard: Provides a high-purity benchmark for analytical method development, validation, and quality control in related API manufacturing.

Basic Information

Product Name	D-Threo-1-Phenyl-2-Hexadecanoylamino-3-Morpholino-1-Propanol Hydrochloride
CAS No.	139889-65-9
Molecular Formula	C29H51ClN2O3
Molecular Weight	511.18 g/mol
Synonyms	D-threo-PDMP hydrochloride; D-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol hydrochloride; (2S,3R)-1-Phenyl-2-hexadecanoylamino-3-morpholino-1-propanol hydrochloride; D-threo-PPMP HCl; Glucosylceramide Synthase Inhibitor (D-threo form); PDMP (D-threo) HCl; (1R,2S)-2-Hexadecanoylamino-3-morpholino-1-phenyl-1-propanol hydrochloride
EINECS	Contact for details

Quality Control

Our D-Threo-1-Phenyl-2-Hexadecanoylamino-3-Morpholino-1-Propanol Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports research requiring high-purity reference standards and intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.