Description

Mad-3 Protein is a high-purity biochemical reagent with the CAS registry number 139874-52-5, essential for advanced life science research and development. This protein plays a critical role in cellular signaling pathways, making it a valuable tool for studying apoptosis, cell cycle regulation, and protein-protein interactions. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology and neurodegenerative disease models.

Application

• Biochemical Research: Used as a key reagent in studies of intracellular signaling cascades and enzyme kinetics.
• Pharmaceutical Development: Serves as a target or reference standard in drug discovery programs, particularly for cancer therapeutics.
• Diagnostic Assay Development: Employed in the calibration and validation of ELISA and other immunoassay kits.
• Cell Biology Studies: Essential for investigating mechanisms of programmed cell death (apoptosis) and cellular stress responses.
• Protein Interaction Analysis: Used in pull-down assays, co-immunoprecipitation, and mass spectrometry to map protein networks.
• Academic & Contract Research: A fundamental component for basic research in university and CRO laboratory settings.

Basic Information

Product Name	Mad-3 Protein
CAS No.	139874-52-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	IκBα; NFKBIA; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3; IkB-alpha; NF-κ-B inhibitor alpha; RL/IF-1
EINECS	Contact for details

Quality Control

Our Mad-3 Protein is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including purity assessment by HPLC and identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all quality parameters are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under controlled, dry conditions to prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms
Purity (SDS-PAGE)	≥ 95%
Protein Content (BCA)	≥ 90%
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity	Assessed by functional assay
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.