Description

Calnexin CAS NO 139873-08-8 is a high-purity chemical compound widely recognized for its role as a molecular chaperone in protein folding and quality control within the endoplasmic reticulum. This compound is essential for research and development in biochemistry and cell biology, providing a critical tool for studying cellular stress responses and protein maturation pathways. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in proteomics and drug discovery.

Application

• Biochemical Research: Used as a key reagent in studies of endoplasmic reticulum (ER) function, protein folding, and the unfolded protein response (UPR).
• Pharmaceutical Development: Serves as a target or tool compound in screening assays for therapies targeting protein misfolding diseases, such as neurodegenerative disorders.
• Cell Biology Studies: Employed in immunoprecipitation, Western blotting, and fluorescence microscopy to investigate chaperone-client protein interactions.
• Proteomics & Genomics: Facilitates research into post-translational modification and quality control mechanisms of glycoproteins.
• Diagnostic Reagent Manufacturing: May be incorporated into kits or assays for detecting cellular stress markers or specific protein conformations.
• Academic & Institutional Research: A fundamental material for graduate and post-doctoral research in molecular biology and related life science disciplines.

Basic Information

Product Name	Calnexin
CAS No.	139873-08-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Calnexin; CANX; IP90; p88; Major Histocompatibility Complex Class I Antigen-Binding Protein p88; Calnexin Precursor; Endoplasmic Reticulum Lectin; ER Membrane Protein; Molecular Chaperone Calnexin; 90 kDa Endoplasmic Reticulum Protein
EINECS	Contact for details

Quality Control

Our Calnexin is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including purity assay and identity confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at recommended temperatures (typically 2-8°C or as specified on the label). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent degradation. For long-term stability, consider storage under inert atmosphere or desiccant.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Protein Content	≥ 90%
Endotoxin Level	< 1.0 EU/µg
Biological Activity	Confirmed by functional assay
Solubility	Soluble in appropriate aqueous buffers
Moisture Content	< 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.