Description

Pth-Related Protein Splice Isoform 3 (140-173) (Human) is a defined synthetic peptide fragment corresponding to residues 140-173 of the human parathyroid hormone-related protein splice isoform 3. This high-purity peptide is a critical research tool for studying bone biology, calcium metabolism, and the role of PTHrP in various physiological and pathological processes. It is essential for researchers and developers in pharmaceutical R&D, academic institutions, and biotechnology companies focused on metabolic disorders, cancer research, and therapeutic peptide development. The compound is supplied with the CAS registry number 139872-85-8.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of PTHrP signaling pathways, receptor binding assays, and calcium homeostasis.
• Antibody Production & Immunoassays: Serves as a key immunogen for generating specific antibodies and as a calibrator/control in ELISA and other immunoassay development.
• Drug Discovery & Screening: Employed in high-throughput screening (HTS) platforms to identify and validate novel modulators of the PTH/PTHrP receptor for potential therapeutics.
• Cell Biology Studies: Applied in cell culture experiments to investigate the effects of PTHrP fragments on osteoblast/osteoclast activity, cell proliferation, and differentiation.
• Structural Biology: Utilized in NMR, X-ray crystallography, and other biophysical studies to determine structure-activity relationships (SAR) of PTHrP isoforms.
• Diagnostic Development: Acts as a critical component in the development of clinical diagnostic tests for conditions involving abnormal PTHrP levels, such as humoral hypercalcemia of malignancy.

Basic Information

Product Name	Pth-Related Protein Splice Isoform 3 (140-173) (Human)
CAS No.	139872-85-8
Molecular Formula	C185H301N55O52S
Molecular Weight	~4090.8 g/mol
Synonyms	PTHrP (140-173), Human; Parathyroid Hormone-Related Protein Fragment (140-173); PTHLH (140-173); PTH-Related Protein Peptide (140-173); Splice Isoform 3 of PTHrP (140-173); Hypercalcemia of Malignancy Factor Fragment; Osteostatin-related peptide; PTHrP Isoform 3 Peptide
EINECS	Contact for details

Quality Control

Every batch of Pth-Related Protein Splice Isoform 3 (140-173) (Human) is manufactured and analyzed under strict quality systems. Identity and purity are verified by multiple orthogonal analytical methods, including HPLC and mass spectrometry, to ensure compliance with research-grade specifications. Comprehensive Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with each shipment to guarantee traceability and reproducibility for your critical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This peptide is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. Aliquotting is recommended for repeated use to avoid freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.