Description

Proteoglycan-Associated Protein Ppl is a specialized protein associated with proteoglycan structures, playing a crucial role in extracellular matrix organization and cellular signaling pathways. Its high purity and defined biological activity make it an essential reagent for advanced life science research and biopharmaceutical development. This product is primarily targeted at research institutions, diagnostic kit manufacturers, and biotech companies engaged in studies of connective tissue biology, cartilage research, and the development of novel therapeutic agents.

Application

• Biomedical Research: Used as a critical reagent in studies investigating the structure, function, and assembly of proteoglycans in the extracellular matrix.
• Diagnostic Development: Serves as a reference standard or antigen in the development of immunoassays and diagnostic tests for connective tissue disorders.
• Drug Discovery & Target Validation: Employed in high-throughput screening and target identification for therapies aimed at cartilage degradation, osteoarthritis, and other matrix-related diseases.
• Cell Culture & Tissue Engineering: Utilized as a component in specialized cell culture media or scaffolds to study cell-matrix interactions and promote specific cellular differentiation.
• Biochemical Assay Standard: Acts as a purified protein standard in quantitative assays such as ELISA, Western blotting, and activity-based protein profiling.

Basic Information

Product Name	Proteoglycan-Associated Protein Ppl
CAS No.	139660-56-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PPL; Proteoglycan-Linking Protein; Proteoglycan-Associated Link Protein; Cartilage Link Protein; HA-binding region link protein; Aggrecan Link Protein; HAPLN1 (Hyaluronan And Proteoglycan Link Protein 1); CSPG Link Protein
EINECS	Contact for details

Quality Control

Our Proteoglycan-Associated Protein Ppl is produced under stringent conditions to ensure batch-to-batch consistency and biological relevance. Each lot is characterized using a suite of analytical techniques including SDS-PAGE, HPLC, and mass spectrometry to confirm identity, purity, and activity. A comprehensive Certificate of Analysis (COA), detailing purity, endotoxin levels, and functional assay data, is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. Handle using aseptic techniques to maintain sterility where required.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Complies
Purity (HPLC)	≥ 95%
Protein Content (BCA)	≥ 90%
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity	Assay-dependent; COA provided
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.