Description

(Fmoc-Cys-Otbu)2, (Disulfide Bond) is a protected cysteine derivative dimerized via a disulfide bridge, a crucial intermediate in solid-phase peptide synthesis (SPPS). This compound is essential for the controlled introduction of cysteine residues, enabling the formation of native disulfide bonds that are critical for the three-dimensional structure and biological activity of therapeutic peptides. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing peptide-based drugs, hormones, and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the sequential assembly of peptides containing cysteine, facilitating the formation of intramolecular or intermolecular disulfide bonds.
• Pharmaceutical Research & Development: Used in the synthesis of peptide therapeutics, including hormones, antimicrobial peptides, and targeted cancer therapies where disulfide bonds confer stability and correct folding.
• Bioconjugation and Protein Engineering: Serves as a handle for site-specific modification of peptides and proteins, enabling the attachment of labels, drugs, or polymers.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery programs.
• Production of Biologically Active Peptides: Critical for manufacturing peptides with native disulfide connectivity, such as oxytocin, vasopressin, and conotoxins.

Basic Information

Item	Details
Product Name	(Fmoc-Cys-Otbu)2, (Disulfide Bond)
CAS No.	139592-37-3
Molecular Formula	C38H44N2O8S2
Molecular Weight	720.89 g/mol
Synonyms	Bis(Fmoc-S-tert-butylthio-L-cysteine); Fmoc-Cys(StBu)-OH disulfide; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-(tert-butylthio)-L-cysteine disulfide; Fmoc-Cys(StBu)-OH dimer; Fmoc-S-tert-butylmercapto-L-cysteine disulfide; Fmoc-L-Cys(StBu)-OH disulfide; Fmoc-Cysteine(StBu) disulfide; Fmoc-Cys(StBu) disulfide
EINECS	Contact for details

Quality Control

Our (Fmoc-Cys-Otbu)2, (Disulfide Bond) is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for demanding research and cGMP applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material supporting DMF filings or regulatory submissions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.