Description

Fmoc-Cys(Pam)2-Oh (S) is a specialized, orthogonally protected cysteine derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters for its critical role in enabling the controlled introduction of cysteine residues, which are essential for forming disulfide bridges that define the tertiary structure and biological activity of complex peptides and proteins. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, peptidomimetics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled, sequential incorporation of cysteine into peptide chains using Fmoc-chemistry protocols.
• Therapeutic Peptide Development: Essential for synthesizing peptides containing disulfide bonds, which are common in hormone analogs, antimicrobial peptides, and other bioactive compounds.
• Conjugation and Bioconjugation: The protected thiol group allows for site-specific modifications, labeling, or conjugation to other molecules, proteins, or surfaces after deprotection.
• Peptidomimetic Research: Used in the design and synthesis of modified peptide structures with enhanced stability or activity for drug discovery programs.
• Chemical Biology Probes: Synthesis of tagged or functionalized cysteine-containing peptides used as tools to study protein-protein interactions and enzyme activity.
• GPCR Ligand Synthesis: Construction of peptide ligands for G-protein-coupled receptors, where disulfide bridges are often crucial for binding affinity.

Basic Information

Product Name	Fmoc-Cys(Pam)2-Oh (S)
CAS No.	139573-78-7
Molecular Formula	C31H33NO6S
Molecular Weight	547.66 g/mol
Synonyms	Fmoc-Cys(Pam)2-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-(phenylmethyl)-L-cysteine; Fmoc-S-benzyl-L-cysteine; Fmoc-Cys(Bzl)-OH; Fmoc-L-cysteine(S-benzyl); N-α-Fmoc-S-benzyl-L-cysteine; (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(phenylmethylsulfanyl)propanoic acid; Fmoc-Cys(Bn)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Cys(Pam)2-Oh (S) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material suitable for research and development under controlled conditions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.