Description

Hemoglobin F-Cosenza CAS NO 139568-65-3 is a specific variant of fetal hemoglobin (HbF) characterized by the Cosenza mutation, representing a high-purity biochemical reference material. This compound is critical for advanced hematological research and diagnostic development, providing a precise standard for studying hemoglobinopathies and genetic blood disorders. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in the development of therapies for sickle cell disease and β-thalassemia.

Application

• Biochemical Research Standard: Serves as a purified reference material for studying the structure, function, and oxygen-binding kinetics of mutant fetal hemoglobin.
• Diagnostic Assay Development: Used as a critical calibrant and control in the development and validation of advanced HPLC, electrophoresis, and mass spectrometry-based assays for hemoglobin variant detection.
• Hematology & Genetic Studies: Essential for research into hereditary persistence of fetal hemoglobin (HPFH) and related genetic modifiers that influence the severity of sickle cell disease.
• Therapeutic Target Validation: Employed in pharmaceutical R&D for screening compounds aimed at inducing fetal hemoglobin expression as a treatment strategy for hemoglobin disorders.
• Clinical Laboratory Quality Control: Provides a known positive control for ensuring the accuracy and precision of clinical laboratory testing for rare hemoglobin variants.
• Educational & Reference Material: Used in academic settings for teaching advanced concepts in molecular hematology and protein biochemistry.

Basic Information

Product Name	Hemoglobin F-Cosenza
CAS No.	139568-65-3
Molecular Formula	C2952H4664N812O840S16Fe4
Molecular Weight	~64,500 Da (Tetramer)
Synonyms	Hb F-Cosenza; Fetal Hemoglobin Cosenza variant; Hemoglobin F Cosenza; γ-Globin variant Cosenza; HbF (Cosenza); Hemoglobin F with Cosenza mutation; HbF Cosenza mutant; Fetal hemoglobin with AγT→I substitution
EINECS	Contact for details

Quality Control

Our Hemoglobin F-Cosenza is produced and handled under stringent quality systems to ensure batch-to-batch consistency and integrity for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and spectral properties. We adhere to relevant guidelines for biological reference materials to support your regulatory and publication requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. Aliquot contents upon first use to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (HPLC/MS)	Conforms to Hb F-Cosenza standard
Purity (HPLC)	≥ 95%
Assay (Functional)	≥ 90% of theoretical oxygen binding capacity
Protein Content (UV-Vis)	≥ 90%
Solubility	Clear solution in buffer
Endotoxin	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.