Description

(2E)-4-[(tert-Butoxycarbonyl)Amino]-5-Phenyl-2-Pentenoic Acid is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine and an α,β-unsaturated carboxylic acid moiety. This compound is a critical pharmaceutical intermediate and building block for the synthesis of complex bioactive molecules, including peptide mimetics and enzyme inhibitors. It is essential for research and development teams in the pharmaceutical, biotechnology, and fine chemical sectors requiring advanced chiral intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly protease inhibitors and other targeted therapeutics.
• Peptidomimetics Research: Used to incorporate constrained, unsaturated scaffolds into peptide chains to enhance metabolic stability and biological activity.
• Chemical Biology Probes: Serves as a precursor for creating activity-based probes to study enzyme function and mechanism.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct complex chiral centers present in many active pharmaceutical ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: A valuable starting material for CDMOs (Contract Development and Manufacturing Organizations) producing custom compounds for clients.
• Academic & Institutional Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	(2E)-4-[(tert-Butoxycarbonyl)Amino]-5-Phenyl-2-Pentenoic Acid
CAS No.	139545-04-3
Molecular Formula	C₁₆H₂₁NO₄
Molecular Weight	291.34 g/mol
Synonyms	Boc-DeltaPhe-OH; (E)-4-((tert-Butoxycarbonyl)amino)-5-phenylpent-2-enoic Acid; 4-[(tert-Butoxycarbonyl)amino]-5-phenyl-2-pentenoic Acid; (2E)-4-[(tert-Butoxycarbonyl)amino]-5-phenylpent-2-enoic Acid; Boc-D-δPhe-OH; (E)-Boc-δPhe-OH; δPhe(Boc)-OH; (2E)-4-(Boc-amino)-5-phenyl-2-pentenoic Acid
EINECS	Contact for details

Quality Control

Our (2E)-4-[(tert-Butoxycarbonyl)Amino]-5-Phenyl-2-Pentenoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and comprehensive spectroscopic identification (NMR, IR, MS). A Certificate of Analysis (COA) detailing batch-specific results is provided to ensure traceability and compliance with your research or cGMP guidelines for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.