Description

Retinoblastoma Binding Protein 2 CAS NO 139532-75-5 is a high-purity biochemical reagent of significant interest in molecular biology and oncology research. This protein plays a crucial role in transcriptional regulation and cell cycle control, making it a valuable tool for studying tumor suppressor pathways and epigenetic mechanisms. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in cancer research, drug discovery, and fundamental cellular biology studies.

Application

• Biochemical Research: Used as a key reagent in studies of transcriptional regulation, chromatin remodeling, and the retinoblastoma (Rb) tumor suppressor pathway.
• Cancer Mechanism Studies: Essential for investigating the role of RBP2 in oncogenesis, cell proliferation, and differentiation in various cancer models.
• Epigenetics & Drug Discovery: Serves as a target protein in high-throughput screening assays for identifying novel epigenetic modulators and therapeutic agents.
• Protein-Protein Interaction Analysis: Employed in pull-down assays, co-immunoprecipitation (Co-IP), and other techniques to map interaction networks within the cell.
• Enzymatic Activity Assays: Used in functional studies to characterize the histone demethylase activity of RBP2 and its impact on gene expression.
• Antigen for Antibody Production: Acts as a purified antigen for generating specific polyclonal or monoclonal antibodies for diagnostic and research applications.

Basic Information

Product Name	Retinoblastoma Binding Protein 2
CAS No.	139532-75-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	RBP2; JARID1A; KDM5A; Retinoblastoma-Binding Protein 2; Histone Demethylase JARID1A; Lysine-Specific Demethylase 5A; PLU-1; p150
EINECS	Contact for details

Quality Control

Our Retinoblastoma Binding Protein 2 is produced under stringent quality management protocols to ensure batch-to-batch consistency and high biological activity. Each lot is characterized using advanced analytical techniques, including SDS-PAGE, Western Blot, and functional activity assays. A comprehensive Certificate of Analysis (COA) detailing purity, concentration, and specific activity is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in appropriate aliquots to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert conditions after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (SDS-PAGE)	≥ 90%
Identification (Western Blot)	Positive for RBP2/JARID1A
Protein Concentration	Provided on COA
Specific Activity	Provided on COA
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.