Description

2-([(Benzyloxy)Carbonyl]Amino)-3,3,3-Trifluoro-2-Methylpropanoic Acid is a high-value, non-natural amino acid derivative featuring a trifluoromethyl group and a benzyloxycarbonyl (Cbz) protecting group. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, prized for introducing steric bulk and fluorine atoms to modulate the biological activity and metabolic stability of target molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of fluorinated peptide mimetics, protease inhibitors, and other bioactive molecules where the trifluoromethyl group enhances lipophilicity and metabolic resistance.
• Agrochemical Research: Building block for developing novel herbicides, fungicides, and pesticides that leverage fluorine chemistry for improved efficacy and environmental profile.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis as a protected, fluorinated amino acid analogue to create peptides with modified properties.
• Material Science: Intermediate in the synthesis of specialty polymers and liquid crystals, where the rigid, fluorinated side chain can influence material properties.
• Chemical Biology & Probe Development: Utilized in creating isotopically labeled or fluorescently tagged compounds for mechanistic studies and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex fluorinated intermediates.

Basic Information

Product Name	2-([(Benzyloxy)Carbonyl]Amino)-3,3,3-Trifluoro-2-Methylpropanoic Acid
CAS No.	139520-43-7
Molecular Formula	C13H14F3NO4
Molecular Weight	305.25 g/mol
Synonyms	N-Cbz-3,3,3-Trifluoro-2-methylalanine; (2R/S)-2-[[(Benzyloxy)carbonyl]amino]-3,3,3-trifluoro-2-methylpropanoic acid; 2-[(Benzyloxycarbonyl)amino]-3,3,3-trifluoro-2-methylpropionic acid; Cbz-3,3,3-Trifluoro-2-methyl-Ala-OH; Z-3,3,3-Trifluoro-2-methyl-Ala-OH; 2-Methyl-3,3,3-trifluoroalanine N-benzyloxycarbonyl derivative; 139520-43-7; N-Carbobenzoxy-3,3,3-trifluoro-2-methylalanine
EINECS	Contact for details

Quality Control

Our production of 2-([(Benzyloxy)Carbonyl]Amino)-3,3,3-Trifluoro-2-Methylpropanoic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and NMR for structural confirmation, to ensure compliance with exacting customer specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development through research-grade to GMP-grade material, with documentation tailored to regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.