Description

(3R-Trans)-[2-[3,5-Bis[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclohexylidene]Ethyl]Diphenyl-Phosphine Oxide is a sophisticated organophosphorus compound featuring a sterically protected, chiral diol core. This compound matters as a highly valuable chiral ligand or intermediate in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily needed by research institutions and pharmaceutical companies engaged in developing novel therapeutic agents and advanced catalytic processes.

Application

• Asymmetric Catalysis: Serving as a chiral ligand for transition metal catalysts in enantioselective hydrogenation, cross-coupling, and other C-C bond-forming reactions.
• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex, chiral active pharmaceutical ingredients (APIs).
• Methodology Development: Used in academic and industrial R&D for developing new synthetic methodologies and catalytic systems.
• Fine Chemical Synthesis: Enabling the production of high-value, enantiomerically enriched agrochemicals, flavors, and fragrances.
• Chiral Auxiliary: Potentially employed as a temporary chiral controller in diastereoselective synthesis.
• Material Science Research: Investigated for creating chiral frameworks in advanced polymeric or supramolecular materials.

Basic Information

Product Name	(3R-Trans)-[2-[3,5-Bis[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclohexylidene]Ethyl]Diphenyl-Phosphine Oxide
CAS No.	139356-39-1
Molecular Formula	C38H55O3PSi2
Molecular Weight	647.00 g/mol
Synonyms	(3R-trans)-2-[3,5-Bis[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1-cyclohexylidene]ethyldiphenylphosphine oxide; (3R-trans)-[2-(3,5-Bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethyl]diphenylphosphine oxide; (R,R)-TBS-Cholane Phosphine Oxide Ligand Precursor; trans-(3R)-3,5-Bis-O-(tert-butyldimethylsilyl)-1-cyclohexylideneethyldiphenylphosphine oxide; Chiral Diol TBS Ether Phosphine Oxide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) detailing specifications such as assay (HPLC/NMR), enantiomeric excess, and impurity profiles are available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.