Description

2-Chloro-4,5-Difluorobenzoylacetonitrile is a versatile and high-purity fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique molecular structure, featuring both chloro and difluoro substituents on the benzoylacetonitrile core, makes it a critical building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorinated aromatic scaffold to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs), due to its electron-withdrawing characteristics.
• Custom Synthesis and Contract Manufacturing: An essential reagent for fine chemical companies offering bespoke synthesis services for complex, fluorinated target molecules.

Basic Information

Product Name	2-Chloro-4,5-Difluorobenzoylacetonitrile
CAS No.	139218-69-2
Molecular Formula	C9H4ClF2NO
Molecular Weight	215.58 g/mol
Synonyms	2-Chloro-4,5-difluorobenzoylacetonitrile; 3-(2-Chloro-4,5-difluorophenyl)-3-oxopropanenitrile; 2-Chloro-4,5-difluorobenzoyl methyl cyanide; 1-(2-Chloro-4,5-difluorophenyl)-2-cyanoethanone; (2-Chloro-4,5-difluorobenzoyl)acetonitrile; 139218-69-2; Propanenitrile, 3-(2-chloro-4,5-difluorophenyl)-3-oxo-
EINECS	Contact for details

Quality Control

Our 2-Chloro-4,5-Difluorobenzoylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.