Description

2,2-Difluorocitric Acid is a fluorinated derivative of citric acid, serving as a key chiral building block and intermediate in advanced organic synthesis. Its unique structure, featuring two fluorine atoms at the 2-position, is critical for modulating the biological activity and metabolic stability of target molecules. This high-purity intermediate is essential for research and development in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and production of fluorinated drug candidates, including protease inhibitors and enzyme modulators.
• Agrochemical Synthesis: Used in developing advanced fluorinated pesticides and herbicides, where the fluorine atoms enhance compound stability and efficacy.
• Biochemical Research: Serves as a substrate analog or inhibitor in enzymatic studies, particularly those involving citrate metabolism or fluorinated metabolite pathways.
• Organic Synthesis Building Block: Employed in asymmetric synthesis and medicinal chemistry to introduce a fluorinated citric acid moiety into complex molecular architectures.
• Material Science Precursor: Potential use in synthesizing specialized fluorinated polymers or ligands for catalytic systems.

Basic Information

Product Name	2,2-Difluorocitric Acid
CAS No.	139182-83-5
Molecular Formula	C6H6F2O7
Molecular Weight	228.11 g/mol
Synonyms	2,2-Difluorocitric Acid; 2,2-Difluoro-2-hydroxybutane-1,2,4-tricarboxylic Acid; (1R,2S)-1-Fluoro-2-hydroxy-3,4-dicarboxybutyric Acid; Difluorocitrate; 2,2-Difluorocitrate; NSC 339313; 139182-83-5 (CAS).
EINECS	Contact for details

Quality Control

Our 2,2-Difluorocitric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.