Description

α-Ketoglutarate Permease, E Coli CAS NO 139172-03-5 is a specialized membrane transport protein that facilitates the uptake of α-ketoglutarate into bacterial cells. This compound is of significant value in biochemical research and industrial microbiology for studying metabolic pathways and transport mechanisms. It is primarily needed by researchers and developers in the fields of enzymology, metabolic engineering, and pharmaceutical development, particularly for applications involving Escherichia coli as a model organism or production host.

Application

• Biochemical Research: Fundamental studies on bacterial amino acid and carbon metabolism, specifically the citric acid cycle.
• Enzyme Mechanism Studies: Investigation of substrate specificity, kinetics, and inhibition of dicarboxylate transport systems.
• Metabolic Engineering: A key component in engineering E. coli strains for the enhanced production of glutamate, glutamine, and related compounds.
• Pharmaceutical Development: Used in research targeting bacterial nutrient uptake as a potential avenue for novel antibiotic strategies.
• Diagnostic Reagent Manufacturing: Potential use as a purified component in enzymatic assay kits for clinical or research diagnostics.
• Academic & Industrial R&D: Serves as a critical reagent for laboratories focusing on microbial physiology and synthetic biology.

Basic Information

Product Name	α-Ketoglutarate Permease, E Coli
CAS No.	139172-03-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2-Oxoglutarate permease; α-Ketoglutarate transporter; KgTP; Dicarboxylate transporter; α-KG permease; E. coli α-ketoglutarate carrier protein; Membrane transport protein for oxoglutarate
EINECS	Contact for details

Quality Control

Our α-Ketoglutarate Permease is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and biological activity. The product undergoes rigorous analytical testing, which may include assessment of purity, protein concentration, and functional activity. Certificates of Analysis (COA) detailing specific lot results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solution
Identification (Functional Assay)	Confirms transport activity for α-ketoglutarate
Purity (SDS-PAGE)	≥ 90%
Protein Concentration	As per COA (Bradford/BCA assay)
Specific Activity	Contact for details
Endotoxin Level	< 1.0 EU/µg (for research-grade applications)
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.