Description

Fmr-1 Protein CAS NO 139135-51-6 is a purified recombinant protein derived from the Fragile X Mental Retardation 1 (FMR1) gene. This protein is a critical research tool for studying the molecular mechanisms underlying Fragile X syndrome, the most common inherited form of intellectual disability and autism. It is essential for scientists and R&D professionals in neuroscience research, molecular biology, and pharmaceutical development focused on neurodevelopmental disorders and targeted therapeutics.

Application

• Biochemical Research: Used as a standard or substrate in enzymatic assays to study the function and interactions of the FMR1 protein.
• Neuroscience Studies: Critical for investigating synaptic plasticity, neuronal development, and the pathophysiology of Fragile X syndrome.
• Antibody Production & Validation: Serves as a high-purity antigen for generating and testing specific antibodies for diagnostic or research applications.
• Drug Discovery & Screening: Employed in high-throughput screening (HTS) platforms to identify potential therapeutic compounds that modulate FMR1 protein activity.
• Protein-Protein Interaction Analysis: Utilized in pull-down assays, co-immunoprecipitation (Co-IP), and surface plasmon resonance (SPR) to map binding partners.
• Diagnostic Development: Acts as a key component in the development of immunoassays for research-based detection of FMR1-related biomarkers.

Basic Information

Product Name	Fmr-1 Protein
CAS No.	139135-51-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	FMR1 Protein; Fragile X Mental Retardation 1 Protein; FMRP; FXR1P; AGO2; dFMR1; dFXR; FMR1; FMR1_HUMAN; Recombinant Human FMR1 Protein
EINECS	Contact for details

Quality Control

Our Fmr-1 Protein is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous quality testing, including purity analysis and functional validation, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, concentration, endotoxin levels, and activity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE)	≥ 90%
Identification (Mass Spec)	Conforms
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity	Assay-specific; detailed data on COA
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.