Description

Tris-(2-Maleimidoethyl)Amine (Trifunctional) (TMEA) is a specialized trifunctional crosslinking agent featuring three reactive maleimide groups. This compound is essential for creating highly stable, three-dimensional polymer networks through Michael addition or radical reactions with thiols, amines, or other nucleophiles. It is a critical material for researchers and manufacturers in the advanced polymer, bioconjugation, and high-performance materials sectors seeking to enhance thermal stability, mechanical strength, and covalent bonding precision.

Application

• Advanced Polymer Synthesis: As a core building block for high-performance thermosetting resins, epoxy hardeners, and polyimide precursors.
• Bioconjugation & Protein Modification: For creating stable antibody-drug conjugates (ADCs), enzyme immobilization, and site-specific protein crosslinking via thiol-maleimide chemistry.
• Hydrogel & Biomaterial Fabrication: Enables the formation of robust, covalently crosslinked hydrogels for tissue engineering, drug delivery systems, and 3D cell culture scaffolds.
• Adhesives & Sealants: Imparts superior thermal and chemical resistance in specialty adhesives, potting compounds, and electronic encapsulants.
• Surface Coating & Modification: Used to functionalize surfaces (e.g., nanoparticles, chips, membranes) with reactive handles for further chemical grafting.
• Dendrimer & Hyperbranched Polymer Synthesis: Serves as a versatile trifunctional core for constructing complex, well-defined macromolecular architectures.

Basic Information

Product Name	Tris-(2-Maleimidoethyl)Amine (Trifunctional) (TMEA)
CAS No.	139112-38-2
Molecular Formula	C18H21N3O6
Molecular Weight	375.38 g/mol
Synonyms	Tris(2-maleimidoethyl)amine; TMEA; N,N-Bis(2-maleimidoethyl)-2-maleimidoethanamine; 2,2',2''-Nitrilotris(ethylmaleimide); 1,1',1''-Nitrilotris(2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethane); Trifunctional Maleimide Crosslinker; Tris-maleimide crosslinker
EINECS	Contact for details

Quality Control

Our Tris-(2-Maleimidoethyl)Amine (TMEA) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets precise specifications for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term stability to prevent moisture absorption and premature polymerization.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.