Description

Core I Protein, Ubiquinol-Cytochrome C Reductase is a highly purified mitochondrial membrane protein complex, also known as Complex III, essential for the electron transport chain. This critical enzyme catalyzes the transfer of electrons from ubiquinol to cytochrome c, playing a pivotal role in cellular respiration and ATP synthesis. It is indispensable for researchers in biochemistry, molecular biology, and pharmacology, as well as for diagnostic kit manufacturers focusing on mitochondrial function and metabolic disorders.

Application

• Biochemical Research: Fundamental studies on mitochondrial electron transport, oxidative phosphorylation, and cellular bioenergetics.
• Enzyme Activity Assays: Used as a standard or active component in in vitro assays to measure Complex III activity and screen for inhibitors or activators.
• Diagnostic Development: A key reagent in the development of diagnostic tests for mitochondrial diseases and disorders related to energy metabolism.
• Pharmaceutical Research: Target protein for drug discovery efforts aimed at modulating cellular energy production, particularly in areas like ischemia-reperfusion injury and neurodegenerative diseases.
• Educational Use: A valuable teaching tool in advanced university laboratories for demonstrating principles of enzymology and bioenergetics.

Basic Information

Product Name	Core I Protein, Ubiquinol-Cytochrome C Reductase
CAS No.	139047-33-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Complex III; Ubiquinol-Cytochrome C Reductase; Coenzyme Q-Cytochrome C Reductase; Mitochondrial Electron Transport Complex III; Cytochrome Bc1 Complex; EC 1.10.2.2; QCR; Core 1 Protein
EINECS	Contact for details

Quality Control

Our Core I Protein, Ubiquinol-Cytochrome C Reductase is produced and tested under stringent conditions to ensure high biological activity and purity, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing specific activity, purity profile, and functional data. We adhere to rigorous internal quality standards to guarantee batch-to-batch consistency and reliability for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (SDS-PAGE)	Corresponds to characteristic band pattern
Purity (SDS-PAGE)	≥ 90%
Specific Activity	Contact for details (μmol cytochrome c reduced/min/mg protein)
Protein Concentration	As per COA
Buffer Composition	Specified on COA
Solubility	Reconstitutes in appropriate buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.